Tourism, hotel and restaurant activities are a complex socio-economic phenomenon that constantly grows exponentially and in quantity and quality. It provides satisfaction for numerous users and it brings a significant financial income to participants in offering various primary, secondary and tertiary activities. This extremely dynamic economic process demands integral management of organisation and processes which take place during the primary tourism, hotel and restaurant activities, but they also depend upon supporting activities: health, transport, infrastructure, safety, cultural, entertaining and other related activities. During the dynamic working process enterprises in tourism, hotels and restaurants are constantly exposed to undesirable (and criminal) external, but also internal incidents that undermine their financial stability and even existence. Some of these endangering, undesirable incidents caused by criminal attacks on this susceptible economic activity are examined in the dissertation: "Modelling of protection system of enterprises in tourism from economic crime". Based on the given hypotheses, investigative instruments are traced, method system by which constants are identified that appear in the acting process of an abstract enterprise in tourism as well as a method system by which the variables of endangering the technological process of enterprise in achieving the expected planned profit. Relations that exist on the scientific level of the economic, legal and sociologic sciences are explored theoretically, and they determine relations in application of these doctrines in the technological working process of the tourist companies. When defining the nature of business relations, processes are found that do not contribute to profitability of the enterprise, inversely harm the enterprise existence and succumb to illegal appropriation. Overcoming of the unwanted economic effects with the use of proactive model of protection, accepted by the equal managerial component of integral system of the enterprise management, based on scientific and empiric researches is an imperative of every modern enterprise in tourism, regarding contemporary dynamic processes in global world economy. The effect of economic crime on the existing economic system in Croatia and on tourism as the leading economic activity is explored. Empiric knowledge is gained on the existence of criminogenic zones in enterprises for development of an original model of enterprise protection competent to confront timely to all criminal phenomena tourist enterprise business process.