Aim: Aim of this research was to establish if significant differences exist regarding sexual self-perception of patients suffering from schizophrenia or depression, compared to healthy individuals. More specific, we sought to establish possible influences of personality factors on the aspects of sexual self-perception and sexual intercourse of patients suffering from schizophrenia and depression, as well as healthy individuals. Furthermore, establishing possible influence of psychopharmacs and socio-demographic factors (gender, age, marital status, level of education, religious denomination) on the aspects of sexual self-perception and sexual intercourse was also a part of this research. Participants and methods: This research was conducted on 100 patients suffering from schizophrenia and 100 patients suffering from depression, who have been treated with psychopharmacs for at least ten years, and 100 randomly selected healthy volunteers. All participants were informed about the various types of testing used in this research and gave their written informed consent about participating in this research. Schizophrenia and depression were diagnosed according to DSM-IV criteria and the intensity of schizophrenia symptoms was established by a score on the PANSS scale (Positive and negative symptom scale) while the intensity of depression was assessed by MADRS scale (Montgomery-Asperg depression rating scale). Bezinović's questionnaire was used in order to assess seven aspects of sexual self-perception. That questionnaire consists of 57 items regarding seven aspects of sexual self-perception (sexual self-scheme, sexual consciousness, sexual readiness, sexual adventurism, negative emotionality, sexual incompetence and sexual satisfaction). ASEX scale (Arizona sexual experiences scale) was used to research sexual intercourse and sexual dysfunctions caused by the use of psychopharmacs. It consists of five questions separate for male and female gender; first two of which are obligatory and the following three apply only if participant had sexual intercourse during the month prior to completing the scale. International Personality Item Pool (IPIP) was used to research personality traits. IPIP consists of 44 items and measures five personality dimensions (extraversion, neuroticism, conscientiousness, pleasantness and openness to experience). Results: Results show that personality traits of patients suffering from schizophrenia or depression and healthy individuals significantly differ. Furthermore, sexual experiences of patients suffering from schizophrenia or depression and healthy individuals also significantly differ, and patients suffering from depression have more pronounced sexual dysfunctions compared to patients suffering from schizophrenia and healthy individuals. Among patients suffering from schizophrenia or depression, sexual experiences are significantly correlated to personality traits. Therefore, personality traits can predict certain sexual experiences. There are no differences regarding sexual self-perception between patients suffering from schizophrenia and those suffering from depression. Healthy individuals exhibit significantly different sexual self-perception than patients suffering from schizophrenia or depression due to the fact that on all of the observed scales they achieve significantly better results. Personality traits, which are significantly related with better or worse sexual self-perception, of patients suffering from schizophrenia or depression differ from those of healthy individuals. In that manner, personality traits can become predictors of sexual self-perception. Sexual experience is significantly related to sexual self-perception of patients suffering from schizophrenia or depression and differs to that of healthy individuals. In that manner, sexual experience can become predictor of sexual self-perception. Antipsychotics and antidepressants can significantly alter sexual experience and sexual self-perception. Their influence on sexual experience is more significant than on sexual self-perception. Gender also influences sexual experience and sexual self-perception. Female gender is a predictor for a higher number of sexual dysfunctions and worse sexual self-perception among patients suffering from schizophrenia or depression, as well as healthy individuals. Age has a more pronounced effect on sexual self-perception than on sexual experiences of patients suffering from schizophrenia or depression. Marriage is a bad predictor for sexual experiences of patients suffering from depression and healthy individuals, but that is not the case with patients suffering from schizophrenia. Higher level of education is related to fewer sexual dysfunctions and better sexual self-perception of patients suffering from depression and healthy individuals. Number of hospitalizations and length of treatment of patients suffering from schizophrenia or depression does not influence sexual experiences and sexual selfperception. Religious denomination has an influence on sexual experiences and sexual selfperception of patients suffering from schizophrenia and healthy individuals. Conclusion: We can conclude that personality traits can predict sexual self-perception and sexual experiences of patients suffering from schizophrenia or depression, as well as healthy individuals, but socio-demographic factors and psychopharmacs also need to be taken into account when assessing the full influence of personality traits.